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It is the result of education, care, and consistent leadership

The LEADER trial showed that liraglutide reduced the risk of MACE by 13% in patients with type 2 diabetes mellitus and high cardiovascular risk,81 whereas the SUSTAIN-6 trial confirmed that semaglutide significantly lowered the incidence of MACE by 26% compared to placebo.82 More recently, the SELECT trial provided compelling evidence that semaglutide reduced MACE by 20% in individuals without diabetes who are overweight or obese, highlighting its cardioprotective role beyond glycemic control.83 Additionally, GLP-1 receptor agonists have anti-inflammatory properties that may improve vascular health by reducing the levels of pro-inflammatory cytokines and oxidative stress, which are key drivers of vascular dysfunction in CMS

As mentioned earlier, a major role of NADPH is to detoxify ROS, which are intracellular chemical species that contain oxygen (O 2 ) and are reactive toward lipids, proteins, and DNA

Preparation of whole cell lysates and analysis by western blotting HCT116 dTAG-SNIP1 cells were plated onto 10 cm plates to reach 50% confluency at the day of experiment