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Normally, the excess of ROS in the mitochondria is neutralized by the endogenous antioxidant system which comprises several enzymes and non-enzymatic antioxidants [100] including reduced glutathione (GSH), vitamins C, and E, the Cu/Zn-superoxide dismutase (SOD) in the cytoplasm, and Mn-SOD in the mitochondrial matrix, catalase in the peroxisomes, glutathione peroxidase (GSH-Px), etc

Continued preclinical research may clarify how each molecule contributes to structural recovery, cellular communication, and immune homeostasis within the broader context of regenerative biology

Sleeping fewer than six hours per night reduces glutathione synthesis and impairs the glymphatic clearance system that depends on it

Gastroenterology 120 , 411422 (2001)