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Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder

65 However, as this was an open-label, uncontrolled trial, it is impossible to assess how much of the improvement was due to a placebo effect

Some compounds (e.g., EGCG) exhibited inconsistent results, such as inhibiting beneficial bacteria, such as Bifidobacterium