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Although the reduced food intake stimulated by tirzepatide is considered to be the main contributor to the reduced body weight,30 other mechanisms, including increased energy expenditure induced by tirzepatide, may contribute to the reduced body weight and liver fat content.1, 31 An ongoing clinical trial whose main purpose is to investigate the effect of tirzepatide on energy expenditure and food intake in obese patients (NCT04081337) will provide more information on the mechanism by which tirzepatide treatment reduces body weight