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Many studies have indicated that mitochondria are potential targets for the prevention and treatment of obesity or type 2 diabetes (61)

Diencephalon The arcuate nucleus (ARC) of the hypothalamus plays a particularly important role in the central regulation of food intake ( in situ hybridization ( In vitro patch-clamp electrophysiological recordings revealed that modulating the electrophysiological properties of both POMC and cocaine- and amphetamine-regulated transcript (CART) neurons (POMC/CART neurons) and NPY/AgRP neurons are the possible mechanism of liraglutide-induced weight loss ( + -permeable TRPM4 and TRPM5 channels ( GABA released by the NPY/AgRP neurons is very important to the control of food intake probably via inhibiting the anorectic effects of the POMC neurons

Here are the primary candidates and what the evidence shows for each

Additionally, senescent cells secrete a range of chemokines, cytokines, and growth factors, collectively known as the senescence-associated secretory phenotype (SASP) [31]