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From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).

Amylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity

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Recent studies have also uncovered the regulatory role of non-coding RNAs (e.g., circCDYL [60], LncMIR210HG [142], circ-calm4 [145], circMyst4 [146], chromatin-associated circ RNA SCN8A [143]) in ferroptosis, revealing opportunities for RNA-based interventions