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A previous real-world study on SGLT2i therapy showed a promising reduction in HbA 1c , weight and insulin requirements in type 1 diabetes but did not present long-term safety or reno-cardiovascular outcome data [25]

Local NETendothelium interactions can impair nitric oxide bioavailability, expose subendothelial matrix, and promote leukocyte and platelet adherenceevents that collectively accelerate a pro-atherogenic, pro-thrombotic vascular phenotype in PCOS [70]

Ozempic, Mounjaro, and Rybelsus are approved for type 2 diabetes, so prescribing them for weight loss is an off-label use

Figure 2F shows the contribution of most lipid species not including cholesterol