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albicans , as a typical opportunistic pathogenic fungus, possesses a strong pathogenicity due to the coordinated regulation of multiple virulence traits, which collectively support its transformation from a commensal to a pathogenic state

The reactive metabolite of Hcy, thiolactone, can bind to the amino groups of lysine in susceptible proteins of the cell, including the cytochrome c complex, which is involved in the electron transfer from complex III to IV [20]

Third, GSNO interacts with E3 ubiquitin ligase C-terminus Hsc70 interacting protein (CHIP), inhibiting CHIP-CFTR interaction and reducing CFTR ubiquitination, which increases both mature and immature F508del-CFTR levels and enhances cell surface expression (Zaman et al., 2019)

It ensures the factory has the workers it needs and prevents the finished product from being wasted on minor tasks