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Acknowledgements We would like to thank Xiaoju Li and Haiyan Sui from Life Science General Research Technology Platform of SKLMT (State Key Laboratory of Microbial Technology, Shandong University) for the assistance in X-ray diffraction experiment

Contraindications: Active malignancy (GH/IGF-1 can promote tumor growth), pregnancy (Category Xevidence of fetal risk), hypersensitivity to tesamorelin or mannitol