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Specifically, astrocyte-derived IL-33 recruits and directs microglial synaptic pruning, a critical step in neural circuit maturation [99]

The 10 structural models with the lowest associated energy from 100 calculated structural models were used to prepare figures using the PyMOL Molecular Graphics System, Version 2.4 (Schrdinger, LLC)

Linnerbauer and Rothhammer, 2020)

Herein, we review outcomes from recent mouse models where gut permeability was altered by direct and indirect effects of manipulating mucosal barrier-associated proteins, to highlight the significance of mucosal permeability and the non-barrier-related roles of these proteins in regulating chronic mucosal inflammatory conditions