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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis
Indeed, in the first report that demonstrated a significant role of ceramide in erythrocyte death pathways, it has been ruled out that the elevated ceramide levels originate from the biosynthetic pathway [122]
doi: 10.1038/nprot.2007.94 Jackson, S
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