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The compound leverages the known effects of the natural gut hormone oxyntomodulin, which has been shown to decrease food intake and increase energy expenditure in humans as well as the established effects of GLP1 agonism on both glucose control and body weight
doi: 10.1681/ASN.2013080830 45 SwigrisJJBrownKK
The GLP-1 group also had a higher kidney cancer risk at 3 years (HR = 2.09
The concentration of GSH that is normally about 400 M in the epithelial lining fluid, over a 100-fold higher than in plasma, is low in the airways of patients with cystic fibrosis from an early age (112114)
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