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76 During airway differentiation, inhibition of the Wnt/-catenin pathway contributes to the rapid directional differentiation of pluripotent stem cells into proximal airway epithelial cells, while activation of the Wnt/-catenin pathway promotes formation of the distal airway epithelium

New England Journal of Medicine (2025) 2

There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic