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S., Earleywine, M., Musty, R

Stroke is clinically defined as a neurological deficit attributed to an acute focal injury of the central nervous system (CNS) (i.e., brain, spinal cord, or retina) by a vascular cause (i.e., infarction, hemorrhage) (2)

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies