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Disrupted cortisol patterns help explain many of the symptoms long COVID patients consistently report, including: Fatigue Sleep dysfunction Inflammatory amplification Poor stress resilience Gut Microbiome Disruption COVID-19 causes significant gut microbiome disruption during acute infection, and research shows this disruption can persist for months in long COVID patients

However, the induction of EBV reactivation was highly attenuated in cells knocked down for p53 expression, but not in cells knocked down for GFP expression (Figure 5A)