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Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers
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CPAA (2022) 14:1926
Ochronosis was most often reported in middle-aged women (53.2%), of African descent (45.2%), Black races (55.5%), and Fitzpatrick skin types V-VI (52.4%)
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