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As a small molecule that mimics and potentiates HGF activity while maintaining oral bioavailability and blood-brain barrier penetration, Dihexa offers practical advantages over gene therapy or protein-based approaches for clinical translation

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These are not minor caveats they are the central limitation of the current evidence

However, different results were found in male BALB/c mouse brains, where GLUD1 levels did not change with aging from 3 to 26 months in the cerebral cortex, hippocampus, or striatum, but enzyme activity increased with aging in the cerebral cortex