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Vitamin B12 has a good safety profile, but some important considerations include rare hypersensitivity reactions (including anaphylaxis) with injections, potential hypokalaemia during early treatment of severe deficiency, and possible cutaneous reactions

B12 injections have very low toxicity, but adverse reactions can occur

Chelators can strip copper from the GHK-Cu component, and reducing agents may affect peptide stability during prolonged exposure in the same buffer

When NNMT runs high, the result in tissue models is more fat storage, less fatty-acid oxidation, weaker mitochondrial performance and a lower metabolic rate