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Low red blood cell counts (anemia) due to vitamin B12 deficiency

People with gastrointestinal conditions Conditions like celiac disease, Crohn disease, or other malabsorption syndromes already impair B12 absorption

This pilot study suggest that the nasal drops may be used as an alternative to injections because two thirds of ME/CFS patients reported a positive effect, accompanied by an increased number of steps, improvement of the RAND-36 physical functioning scale and the CIS20r fatigue scale, and a significant increase in serum vitamin B12 levels

GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials