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Again, CS might be fundamental not only to produce but also to transport acetyl-CoA from the mitochondria to the nucleus for supplying acetyl-CoA for histone acetylation

Another enzyme, S-adenosylmethionine decarboxylase (AMD1), which is a key enzyme for the synthesis of polyamines [50], showed a value of log2FC 1.49 at 3 DPI vs CK (Additional file 1: Dataset S1), indicating that fungal polyamine biosynthesis was up-regulated in the intermediate infection stage compared with the CK

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This results in IFN- secretion from Th1 cells and is followed by proinflammation at the infected site