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A more targeted approach, including phage therapy, could be considered to specifically eradicate immune-mimicking gut commensals without compromising immunotherapy outcomes (Mandelbaum et al., 2020)

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The shotgun analysis yielded highly similar overall differences in microbiome signatures in the study groups as also identified by 16S sequencing (Figs 2A,B and 4A,B), further supporting the observation that liraglutide and GUB09-145 treatment resulted in larger microbiome compositional changes compared to vehicle-dosed DIO mice