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Although the concept of overtourism is considered a relatively new phenomenon in the literature, studies on the impacts of tourism on settlements have been conducted in various fields since the 1960s

These local hepatic alterationswhen coupled with systemic inflammation, dysregulated adipokines (e.g., leptin, adiponectin), and circulating profibrotic cytokines (e.g., TGF-, IL-13)amplify fibrotic signaling across distant organs (123, 129)

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The majority of patients also tolerate the therapy very well, particularly if in the hands of professional practitioners