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The company will test two different doses in up to six glaucoma patients before establishing a dose to test in up to six NAION patients

The FDAs news release about the approval describes a schedule that gradually increases doses over timea titration scheme similar to that of other GLP-1 drugs that helps the body adjust to the medication, Drucker explains

It works through several mechanisms, including delayed gastric emptying, improved insulin sensitivity, and reduced food cravings

The simultaneous upregulation of TIMP-1 and TIMP-2, the natural inhibitors of MMPs, suggests a regulatory influence of GHK-Cu on the balance between matrix synthesis and matrix degradation (Pickart et al., 2015)