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The pharmacological development of GLP-1 receptor agonists (GLP-1RAs) has focused on introducing specific structural modifications to enhance resistance to DPP-4 degradation, extend half-life, and improve bioavailability
Among the agents with documented body composition data, liraglutide , semaglutide , and exenatide are the most extensively studied single-target GLP-1RAs
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DOX encapsulated in Au nanoparticles showed higher uptake and induced greater cytotoxicity in drug-resistant cells, such as breast cancer cells (417, 418), in addition to the better accumulation of drugs in tumor tissues (419)
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