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The advantages of using Fe 3 O 4 nanoparticles to treat RA through targeted hydroxyl radical release include: precise magnetic field-guided localization to inflamed joints, localized destruction of pro-inflammatory cells, immune modulation with reduced systemic side effects, and enhanced efficacy when combined with photothermal/photodynamic therapies

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Saudi J Health Syst Res 2:2731 Bessone F, Robles-Diaz M, Hernandez N, Inmaculada Medina-Caliz M, Lucena I, Andrade RJ (2019) Assessment of serious acute and chronic idiosyncratic drug-induced liver injury in clinical practice