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Perhaps most surprisingly, we found that T2R-mediated aversive sensory information related to drugs of abuse is routed to the choroid plexus in the fourth ventricle, a secretory organ in the brain, and that manipulating genes in the choroid plexus regulates aversive behavioral responses to addictive drugs

To view a copy of this license, visit About this article Cite this article Psichas, A., Sleeth, M., Murphy, K

10.1038/s41401-021-00726-0 28 LiY.de HaarC.ChenM.DeuringJ.GerritsM

Those who opt for long-term or lifelong use should understand that additional interventions may still be needed if efficacy declines or side effects become significant