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The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

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Wu YZ, Chen WY, Zeng Y, Ji QL, Yang Y, Guo XL, et al

For weight management, treatment duration may depend on achievement and maintenance of weight loss goals, with some patients requiring long-term therapy to maintain weight reduction while others may successfully transition to lifestyle modifications alone after achieving target weight