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The onset of the disease is associated with massive dystrophy and death of astrocytes, which directly correlate to the severity of the disease

J Biosci Bioeng (2006) 101:8796

The kinase activity of nuclear IGF-1R is also implicated in the phosphorylation of histone H3, recruitment of the ATP-dependent helicase Brg1 and the expression of SNAI2 [118], which in turn is involved in cell migration and epithelial-mesenchymal transformation