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Despite disease-modifying therapies being highly effective at arresting acute and peripherally-driven inflammation, benefits on progressive mechanisms of the diseasethose most responsible for irreversible disability accumulation (Bjartmar et al., 2003)appear to be very limited (Filippini et al., 2017

Depending on the initial population density, the number of alive cells grows exponentially (top row - deterministic-growth phase) or decreases exponentially until extinction (bottom row - no-growth phase)

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Samples were processed for histology