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Another advantage is that its excretion is handled more by the liver than the kidney, unlike allopurinol, and febuxostat may thus have some advantage in patients with kidney dysfunction

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Ketone bodies could serve as a potential alternative fuel for failing hearts, bypassing disrupted metabolic pathways such as -oxidation and converting acetoacetate to acetyl-CoA

The latest addition to the evidence is a review of its effects on eye health, with a few cases leading to potentially blinding eye conditions