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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Others propose that liposomes perform the function of penetration enhancers because when applied onto the skin, they break down the cell membranes and diffuse as a lipid mixture