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The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing Current Pharmaceutical Design, 2018;24(18):1972-1989

Adding a second compound while still experiencing significant adverse effects from the first makes it impossible to isolate which agent is responsible for new or worsening symptoms

AOD-9604 was developed to: Stimulate lipolysis (breakdown of stored fat) Inhibit lipogenesis (formation of new fat) Avoid raising IGF-1 levels Reduce impact on blood glucose Because it is a small fragment rather than the full hormone, it theoretically targets fat metabolism more specifically