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It produces greater weight loss than semaglutide, with average reductions of 15-20% body weight in clinical trials

This might include: Keeping a detailed symptom diary during semaglutide initiation Establishing thresholds for concerning symptoms (bloody stools, fever, severe pain) Planning for prompt fecal calprotectin testing or limited sigmoidoscopy if symptoms worsen Scheduling more frequent follow-up during the first 3-6 months of therapy Alternative treatment options should be explored

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