how long can you be on tirzepatide does actually stay in your system after your last dose? It's one of the most common questions we get, and the honest answer is that it depends your How Long Does It Take

The SURMOUNT-1 trial, which followed participants for 72 weeks, demonstrated that patients on the highest dose (15 mg) achieved an average weight loss of 20.9% from baseline, with weight loss continuing throughout most of the study period before stabilizing

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The half-life of GLP-1 in the plasma circulation is only 12 minutes, due to the action of dipeptidyl peptidase (DDP-4) which inactivates GLP-1

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