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In fact, it has been shown that the translation of senescence chondrocytes in mice knee joint resulted in OA phenotype, characterized by leg pain, impaired mobility, and radiographic and histological changes (Xu et al., 2017)

Systemic Inflammation Level of Evidence: Limited evidence While ALCs effects on neuroinflammation are well-documented, evidence for systemic anti-inflammatory effects is more limited

K., Jabbour, S., & Rosenstock, J

Treatments (Clinical) This section provides a clinical treatment overview consistent with ADA Standards of Care in Diabetes2026 for context to support CDI and coding accuracy assessments