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AAP use was also linked to a general decrease in gut microbial diversity, especially in women
The authors of this study also observed that a moderate intake of folic acid in the ART population is associated with reduced DNA methylation variance in imprinting control regions [KCNQ1 overlapping transcript 1 (Kcnq1ot1), small nuclear ribonucleoprotein polypeptide N (SNRPN) and paternally expressed gene 1 (PEG1)] and increased global DNA methylation levels in both embryonic and placental tissues (84)
These pathological alterations ultimately result in irreversible joint deformity and functional impairment, significantly diminishing patients quality of life [2]
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