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An increase in cyclic adenosine monophosphate (cAMP) and a simultaneous dysregulation in intracellular calcium in the cystic epithelium seems to play a key role in generating and maintaining fluid-filled cysts (Yamaguchi et al., 2003
Chem Res Toxicol 2(1):4145 Rashed MS, Myers TG, Nelson SD (1990) Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3-hydroxyacetanilide, in the mouse
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