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The lack of independent replication or detailed data means these findings, while encouraging, are not considered high-quality evidence by todays standards

Moreover, other recent work indicates that the nigro-vagal pathway can modulate tone and motility of the proximal colon via D1-like receptors in the DMV, implying that the colon and small intestine, although both innervated by DMV, are regulated by distinct upstream inputs and receptor pathways 59

This is followed by Stage 2, characterized by IGT without overt diabetes, and culminates in Stage 3, where near-total cell destruction results in symptomatic T1D

Evidence Summary: What the Studies Show Human clinical trials: Kuceki et al