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Rego AC, Oliveira CR (2003) Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases

These can include: Nausea Vomiting Diarrhea or constipation Abdominal pain Most providers start patients on a very low dose and gradually increase it over several months

The extracellular N-terminus contains key regions involved in ligand recognition and binding

Several of these processes are controlled by DHHC-mediated S- palmitoylation of oncogenes or tumor suppressors, including growth factor receptors (e.g., EGFR), kinases (e.g., AKT), and transcription factors (e.g., -catenin)