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Clinical trials of FDA-approved semaglutide and tirzepatide show the difference clearly: Semaglutide patients lose about 15% of total body weight Tirzepatide patients lose approximately 21% Both medications can cause mild gastrointestinal side effects, but tirzepatide is often better tolerated, with many patients reporting fewer symptoms

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If you're taking semaglutide and feeling like you could fall asleep standing up, welcome to the clubyou've got plenty of company