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Consistent with activation of G s , OA caused an increase in cAMP formation in a concentration-dependent manner with an EC 50 of 0.7 0.1 M and a maximum stimulation of 1.20 0.07 pmol/mg protein above basal levels (0.054 0.008 pmol/mg protein) was obtained with 10 M OA (Figure 3B)

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The three predominant forms of carrageenan (kappa, lambda, and iota) are composed of distinct sulfated disaccharides linked by alternating -1,3 and -1,4-glycosidic bonds