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TMLHE mutations make it difficult for neural stem cells to produce energy, or to maintain a correctly oxidized environment, which is why they often dont divide properly

The surgical implantation of the cannula involved anesthetizing the mice with isoflurane

High epidemiological reliability denotes the strongest available evidence with no indication of significant variance or bias ( (i) Persuasive: statistical significance per the random-effects model of p 1,000 cases, low heterogeneity among the selected studies ( I 2 1,000 cases, and most studies indicating a significant effect

Adjusting the dose if side effects, cost, appetite suppression, or maintenance goals change