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doi: 10.14310/horm.2002.1276 84 SzczepanikJPodgrskiTDomaszewskaK

Several large clinical trials have demonstrated that GLP-1 receptor agonists can reduce the risk of cardiovascular events, such as heart attacks and strokes, in people with type 2 diabetes who are at high risk for heart disease

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During PINK1-PARKIN-induced mitophagy, the selective autophagy receptors OPTN and NDP52 redundantly activate TBK1, which in turn phosphorylates the mitophagy receptors OPTN, NDP52 and p62 to ensure their retention at damaged mitochondria and to facilitate the recruitment of ATG8 family proteins (180, 181)