Lu Y, Li C, Liu Y, Wu T, Lu P
Metabolic Effects of DPP-4 Related to Its Enzymatic Activity Despite DPP-4 having a relatively restricted substrate preference (Figure 1), a large number of peptides, proteins, and chemokines still fulfill the criteria and could be predicted to be suitable substrates, and indeed, many have been shown to be cleaved by DPP-4 in pharmacological kinetic, in vitro or animal studies, often using high substrate concentrations (3638)
The most common side effects of GLP-1 are gastrointestinal issues, and some foods may be more likely to increase nausea and stomach discomfort than others while using these meds
The UTI is caused by dehydration and reduced fluid intake, not by tirzepatide itself