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Given the existence of the specific OCTN1 transporter and the selective accumulation in neural and metabolically active tissues, this raises the question of whether the Western decline in mushroom consumption compared to traditional cultures in Asia, where mushrooms have been a staple food for thousands of years may contribute to a chronic undersupply that could correlate with the rise of neurodegenerative disease

CLA safety caveats Certain CLA isomers, particularly the trans 10 cis 12 isomer, have been associated in some studies with worsened insulin sensitivity

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