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Instead, SGLT2is are more effective in the setting of HF and in patients with chronic kidney disease (with or without T2D) for the treatment and prevention of these conditions, whereas GLP-1RAs appear to remain more compelling in weight loss, glycemic control, and cardiovascular benefits in T2D patients [143]
A majority of individuals with severe obesity are not yet on GLP1 therapy
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[124] Other causes of B 12 malabsorption include bariatric surgery, pancreatic insufficiency, obstructive jaundice, tropical sprue, celiac disease, inherited intrinsic factor deficiency, and radiation enteritis affecting the distal ileum
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