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In clinical trials of Wegovy, about 2-3% of adults and 4% of adolescents reported gallstones

But contact your provider if you experience severe or persistent pain at the injection site lasting more than 48 hours, signs of infection such as increasing redness, warmth, swelling, or pus, severe nausea or vomiting that prevents you from keeping fluids down, or any symptoms that feel significantly different from your normal semaglutide experience

That does not mean split dosing cannot work

If a plateau extends beyond 6 weeks and you are not yet at maximum dose, escalating to the next dose level is the standard approach