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This resource was utilized to identify mutations within the GLO-1 gene

In both mouse models and a small human pilot trial, semaglutide shifted chondrocyte (cartilage cell) energy metabolism from inefficient glycolysis toward oxidative phosphorylation

Glutathione-S-transferase (GST) The spontaneous glutathione-s-transferase activity in the kidney of mice was estimated to be 4.55 0.13 nmol/mg protein and treatment of mice with hesperidin increased this activity significantly when compared to non-drug treated control ( Table 2 )

14.2 Weight Management Trial in Pediatric Patients Ages 12 and Older with Obesity SAXENDA was evaluated in a 56-week, double-blind, randomized, parallel group, placebo controlled multi-center trial in 251 pubertal pediatric patients aged 12 to 17 years, with BMI corresponding to 30 kg/m2 or greater for adults by international cut-off points1 and BMI of 95th percentile or greater for age and sex (NCT02918279)