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A 2020 systematic review in the Journal of the American Academy of Dermatology (N=634 across 8 studies) found that oral minoxidil at doses ranging from 0.25 mg to 5 mg daily produced clinically meaningful hair density improvements in 60% to 82% of patients over 6 to 12 months [3]

An argument can therefore be made that the real ALD is actually the adrenomyeloneuropathic form, with the more aggressive cerebral ALD of young boys driven by a superimposed autoimmune inflammation that is secondary to the myelin lipid derangement

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Glucagon receptor activation is minimal at 1-2mg but increases significantly at 4mg and becomes a major driver of the metabolic profile at 8mg and above