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( n = 10) 500 g methylcobalamin was administered intravenously three times a week for six months to patients receiving regular haemodialysis with polyneuropathy secondary to uraemia and diabetes

Aseptic Preparation and Storage: Principles for Clinical Trial Settings Reconstitution of injectable investigational products must be performed by trained personnel following the trial protocol, using the specified diluent, in an appropriate aseptic environment

Optimal results can take up to 16 weeks for some people

This matters for dosing because beta-3 receptor sensitivity varies throughout the day and in response to nutritional status